To the Editor We read the article by Perry and coauthors1 with great interest and anticipation. The authors are to be commended for organizing a substantial cohort to evaluate the differences in oral cavity and oropharyngeal cancer subsite and exposure history. The article provides heightened clinical awareness about trauma as a potential etiologic agent in oral cancer. However, it is unclear why the human papillomavirus (HPV) is included in the title. We noted that no patient HPV data were included in this article to justify the inclusion of HPV in the title. It is common knowledge that head and neck cancer has a multifactorial etiology. Although HPV-induced oropharyngeal cancer is established,2 the contribution of HPV infection to oral cavity carcinogenesis is less well understood.
Frustino JL, Sullivan MA, Rigual NR. Bringing Light to Dental Trauma and Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2015;141(11):1029. doi:10.1001/jamaoto.2015.2407