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Comment & Response
November 2015

Bringing Light to Dental Trauma and Oral Cavity Cancer

Author Affiliations
  • 1Division of Oral Oncology and Maxillofacial Prosthetics, Department of Dentistry, The Center for Oncology Care at Erie County Medical Center, Buffalo, New York
  • 2Department of Head and Neck Surgery/Plastic and Reconstructive Surgery, The Center for Oncology Care at Erie County Medical Center, Buffalo, New York
JAMA Otolaryngol Head Neck Surg. 2015;141(11):1029. doi:10.1001/jamaoto.2015.2407

To the Editor We read the article by Perry and coauthors1 with great interest and anticipation. The authors are to be commended for organizing a substantial cohort to evaluate the differences in oral cavity and oropharyngeal cancer subsite and exposure history. The article provides heightened clinical awareness about trauma as a potential etiologic agent in oral cancer. However, it is unclear why the human papillomavirus (HPV) is included in the title. We noted that no patient HPV data were included in this article to justify the inclusion of HPV in the title. It is common knowledge that head and neck cancer has a multifactorial etiology. Although HPV-induced oropharyngeal cancer is established,2 the contribution of HPV infection to oral cavity carcinogenesis is less well understood.

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