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Comment & Response
November 2015

Assessment of Blinding in a Tinnitus Treatment Trial—Reply

Author Affiliations
  • 1National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, Oregon
  • 2Department of Otolaryngology, Oregon Health & Science University, Portland

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Otolaryngol Head Neck Surg. 2015;141(11):1031-1032. doi:10.1001/jamaoto.2015.2422

In Reply As we stated in Supplement 2 of our recent article1, “Blinding has presented a substantial methodological challenge in previous rTMS studies, primarily because clinicians delivering treatment usually knew when active or placebo stimulation was being administered. In most studies, it was also easy for research subjects to distinguish between active and placebo rTMS conditions.” For this reason, we used a parallel study design, instead of a crossover design, for our clinical trial. Indeed, adequate blinding remains problematic for many clinical trials, particularly those that do not involve pharmacological treatment.2

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