A particularly challenging situation for the head and neck cancer surgeon is the removal of oral cavity cancers with adequate margins of normal-appearing oral mucosa and the management of occult disease. Thus the need for new ways to detect clinically occult fields with high risk for oral cancer. Poh and colleagues report the impact of an optically guided surgical approach for early-stage oral cancer based on the association of cancer development and loss of tissue autofluorescence. Their results suggest that fluorescence visualization may play an important role in the surgical management of patients with oral cavity cancer in the future.
Highlights. JAMA Otolaryngol Head Neck Surg. 2016;142(3):205. doi:10.1001/jamaoto.2015.1791