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To the Editor Noureldine and colleagues1 found that molecular testing with the Afirma gene expression classifier (GEC) did not have a significant effect on the surgical decision-making process for patients with thyroid nodules who presented for surgical consultation. However, this study1 evaluates the test’s performance using an approach that runs counter to the test’s intended use.
Kloos RT, Barth NM. Gene Expression Classifier Testing and the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2016;142(8):806-807. doi:10.1001/jamaoto.2016.0200