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Comment & Response
September 2016

Effect of Basic Fibroblast Growth Factor in Tympanic Membrane Perforation

Author Affiliations
  • 1The Affiliated Yiwu Hospital of Wenzhou Medical College, Zhejiang, China
  • 2Renji College, Wenzhou Medical University, Wenzhou, China
JAMA Otolaryngol Head Neck Surg. 2016;142(9):920-921. doi:10.1001/jamaoto.2016.0580

To the Editor I would like to address the article titled “Preoperative Factors Affecting Tympanic Membrane Regeneration Therapy Using an Atelocollagen and Basic Fibroblast Growth Factor” by Nobuhiro Hakuba et al.1 This work is excellent, and suggests an alternative myringoplasty treatment for chronic tympanic membrane perforation (TMP) that is less invasive, simpler, and more time-saving than temporal fascia or cartilage myringoplasty. However, the description of the regenerative effect of basic fibroblast growth factor (bFGF) in chronic TMP is not appropriate and might easily mislead the reader.

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