What treatment modality gives the best 5-year overall survival (OS) in T3 glottic squamous cell carcinoma (SCC)?
In this secondary analysis of data from the SEER and Medicare databases, among 487 patients with T3 glottic SCC, the adjusted hazard ratio for OS was 0.68 for patients receiving surgery alone vs nonsurgical management and 0.75 for patients receiving surgery plus adjuvant treatment vs nonsurgical management.
The improved OS in patients with T3 glottic SCC receiving surgery reinforces the need to discuss surgery with all of these patients and to maintain surgical arms in all laryngeal cancer studies.
Further investigation is needed in the outcomes of currently available treatment for T3 glottic squamous cell carcinoma (SCC), a unique type of laryngeal cancer.
To compare overall survival (OS) and functional outcomes among patients with T3 glottic SCC receiving nonsurgical and surgical management.
Design, Setting, and Participants
This secondary analysis used data from the Surveillance, Epidemiology, and End Results (SEER) registry and Medicare databases. All patients with T3 glottic SCC who received a diagnosis from January 1, 1992, to December 31, 2010, were included. Data were analyzed from April 2014 to August 2015.
Surgery with or without adjuvant radiotherapy and/or chemotherapy.
Main Outcomes and Measures
Five-year OS and functional outcomes.
Among the 487 patients identified with T3 glottic SCC (418 men [85.8%]; 69 women [14.2%]; median age, 74.3 [interquartile range, 70.4-80.6] years), the 5-year OS for nonsurgical management, surgery alone, and surgery plus adjuvant treatment were 36% (95% CI, 30%-42%), 41% (95% CI, 30%-53%), and 41% (95% CI, 32%-51%), respectively. Multivariable analyses revealed an adjusted hazard ratio for OS of 0.68 (95% CI, 0.49-0.94) for patients receiving surgery alone vs nonsurgical management and 0.75 (95% CI, 0.57-0.98) for patients receiving surgery plus adjuvant treatment vs nonsurgical management. Gastrostomy tube dependence was highest in patients receiving surgery plus adjuvant treatment (30 of 98 patients [30.6%]). Tracheostomy dependence was highest in patients receiving chemoradiotherapy (34 of 92 patients [37.0%]).
Conclusions and Relevance
Overall survival showed a statistically significant and clinically meaningful improvement in patients with T3 glottic SCC who underwent surgery compared with a nonsurgical treatment. Furthermore, the data suggest that adjuvant and nonsurgical treatment result in a dysfunctional larynx; however, this association needs further study.
Al-Gilani M, Skillington SA, Kallogjeri D, Haughey B, Piccirillo JF. Surgical vs Nonsurgical Treatment Modalities for T3 Glottic Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg. 2016;142(10):940-946. doi:10.1001/jamaoto.2016.1609