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Comment & Response
August 25, 2016

Surgical Treatment For T4 Oropharyngeal Cancer—Reply

Author Affiliations
  • 1Department of Otolaryngology–Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri
JAMA Otolaryngol Head Neck Surg. Published online August 25, 2016. doi:10.1001/jamaoto.2016.2239

In Reply We thank Dr Garden1 for his interest and commentary. He brings up 2 general study limitations: the surgical and nonsurgical treatment groups have certain inherent differences, and the nonsurgical treatment paradigms were heterogeneous. These are standard limitations of nonrandomized retrospective research studies. We performed multivariable analyses with propensity weighting to attempt to account for these differences. However, we agree with both of these concerns as delineated in the Discussion section of the manuscript. This is a hypothesis-generating study rather than a hypothesis-proving study.

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