Eosinophilic granuloma is rarely reported within lymph nodes. Furthermore, it is even more rarely reported in the setting of human immunodeficiency virus (HIV) infection. No definitive etiologic association exists between Langerhans cell histiocytosis (LCH) and HIV. However, their potential relationship underscores the significance of cytokines and their influence on biological niches required for Langerhans development and homeostasis.
A 45-year-old man with no remarkable medical history was seen with bilateral nontender cervical lymphadenopathy and a 4.5-kg weight loss during the last 6 months. He had no fever, chills, symptoms of an upper respiratory tract infection, or history of cancer.
Myung PS, Kundu M, Abboud SK. Eosinophilic Granuloma Manifesting as Painless Cervical Lymphadenopathy in a Patient Positive for Human Immunodeficiency Virus 1. Arch Otolaryngol Head Neck Surg. 2008;134(2):203-205. doi:10.1001/archoto.2007.14