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Clinical Problem Solving: Pathology
March 01, 2008

Pathology Quiz Case 2: Diagnosis

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Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Otolaryngol Head Neck Surg. 2008;134(3):336-337. doi:

Solitary fibrous tumor, which is a neoplasm of mesenchymal origin,1was first described in 1931 as a primary spindle cell tumor of the pleura.2Since that time, it has been reported to occur in various subsites of the head and neck, including the nasal cavity, paranasal sinuses, nasopharynx, floor of the mouth, orbit, thyroid gland, larynx, and parapharyngeal space.1,3The tumor rarely occurs in the nasal cavity and paranasal sinuses, with only 26 cases previously reported in the English-language literature, to our knowlege.3,4Although multiple cases of SFT have been reported to extend from the nasal cavity to the surrounding sinuses, we know of only 1 previous report describing intracranial extension from the paranasal sinuses.3Also, a pituitary fossa SFT extending into the adjacent sphenoid sinus has been reported.5An SFT of the nasal cavity with anterior cranial fossa extension is therefore exceedingly rare.

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