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Clinical Problem Solving: Pathology
August 18, 2008

Pathology Quiz Case: Diagnosis

Author Affiliations
 

JULIA C.IEZZONIMD

Arch Otolaryngol Head Neck Surg. 2008;134(8):898. doi:10.1001/archotol.134.8.898

Dermatofibrosarcoma protuberans is a rare, malignant, fibrous histiocytic tumor that is characterized by local infiltrative growth in the dermis of the skin and subcutaneous fat, spreading along the connective tissue. The exact type of dermal mesenchymal cell from which this tumor arises is still unclear, but evidence points toward an origin from either fibroblasts or dendritic cells.1Dermatofibrosarcoma protuberans accounts for fewer than 5% of adult soft tissue sarcomas and fewer than 1% of all malignant tumors of the head and neck.2,3

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