Orofacial granulomatosis (OFG) is an uncommon clinical entity, and not much is known about its pathogenesis. It is a disorder of chronic granulomatous inflammation that characteristically presents with labial enlargement and oral ulceration, but a number of other sites in the oral cavity can also be involved.1,2 The majority of cases of OFG occur in isolation, although a proportion do present in association with established Crohn disease, sarcoidosis, or Melkersson-Rosenthal syndrome.3 There are a number of clinical and histologic similarities between OFG and these conditions, but the exact relationship remains unclear.4 We present a case of OFG as the pathologic mechanism in chronic persistent tonsillitis.
Shakeel M, Newton JR, Sutherland C, Ram B. Orofacial Granulomatosis and Chronic Tonsillitis. Arch Otolaryngol Head Neck Surg. 2009;135(2):202-204. doi:10.1001/archoto.2008.527