KAREN H.CALHOUNMDRONALD B.KUPPERSMITHMD
Carcinoma arising in a TGDR is rare. It is usually diagnosed after the excision of a presumed benign thyroglossal duct cyst. A 1994 review reported 155 cases in the world literature.1 Of these, approximately 80% were papillary or a follicular variant of papillary thyroid cancer. The same review quoted from the Dutch registry a TGDCa incidence of 0.48% (2/413). Unfortunately, since the literature consists of multiple case reports, long-term follow-up on a large series of patients is lacking. Well-differentiated carcinomas of the thyroid gland require long-term follow-up for the survival and disease-free interval data to be valuable. The extrapolation of data from well-differentiated thyroid cancers to TGDCa may not be valid.
Myssiorek D. Total Thyroidectomy Is Overly Aggressive Treatment for Papillary Carcinoma in a Thyroglossal Duct Cyst. Arch Otolaryngol Head Neck Surg. 2002;128(4):464. doi:10.1001/archotol.128.4.464