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Clinical Problem Solving: Radiology
August 2002

Diagnosis Radiology Quiz

Arch Otolaryngol Head Neck Surg. 2002;128(8):980. doi:10.1001/archotol.128.8.979

Sarcoidosis is a systemic granulomatous disease of unknown etiology. It affects a variety of systems, including the nose, lungs (most common), skin, liver, eyes, spleen, and lymph nodes. Although it may affect any ethnic group, it is more prevalent and severe in black persons, usually presenting in the third or fourth decade of life.1

Diagnosis is based on clinical presentation, histologic evidence of noncaseating granulomas, and exclusion of other granulomatous diseases. Differential diagnosis should include histoplasmosis, tuberculosis, berrylliosis, hypersensitivity pneumonitis, lymphoma, and eosinophilic granuloma.2

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