Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases.
To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature.
Case report and literature review.
Main Outcome Measurements
Findings from histologic analysis, immunohistochemistry, and electron microscopy.
An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy.
The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.
Brandwein M, Said-Al-Naief N, Gordon R, Urken M. Clear Cell Odontogenic CarcinomaReport of a Case and Analysis of the Literature. Arch Otolaryngol Head Neck Surg. 2002;128(9):1089-1095. doi:10.1001/archotol.128.9.1089