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Clinical Problem Solving: Pathology
September 2002

Diagnosis Pathology Quiz Case 2

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Arch Otolaryngol Head Neck Surg. 2002;128(9):1102. doi:

Odontogenic keratocyst was first reported by Philipsen1 in 1956. It is classically described as an intraosseous lesion of the jaw that is notorious for its destructive, aggressive nature and high propensity for recurrence. The rates of recurrence vary greatly in the literature, ranging from 5% to 62%.2 The exact pathogenesis of OKCs is unknown, but there are 2 main theories: (1) development from dental lamina or its remnants, and (2) extension of cells from the basal layer or oral epithelium into the mandible or maxilla.

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