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Clinical Problem Solving: Pathology
December 2002

Pathology Quiz Case 2: Diagnosis

Author Affiliations
 

FREDERIC B.ASKINMDWILLIAM H.WESTRAMD

Arch Otolaryngol Head Neck Surg. 2002;128(12):1427. doi:

Tumoral calcinosis, which is a rare disorder of unknown etiology, is characterized by progressively enlarging masses of calcium deposition. It usually occurs in the second or third decade of life and is most commonly seen in African Americans.1 There is no sex predilection, and approximately one third of the cases have a family history that is positive for the disorder. Most experts agree that the disease follows an autosomal recessive inheritance pattern,2 but others insist that it follows an autosomal dominant pattern, with variable expressivity.3 Duret4 is generally credited with describing the first case of this disorder in 1899, and Inclan5 named the disease tumoral calcinosis in 1943. There have been more than 200 cases reported in the literature.

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