The take-home message from our article1 is that patients with well-differentiated thyroid cancer, who present with neck metastases outside the central compartment of the neck, have an approximately 6-fold risk of recurrences, and most of which occur in the neck. This study was retrospective and based on 522 consecutive patients treated between 1964 and 1999 for well-differentiated thyroid cancer.
Freeman JL. The Impact of Nodal Metastases on Prognosis of Well-Differentiated Thyroid Cancer Suggests the Practice of Prophylactic Neck Dissection—Reply. Arch Otolaryngol Head Neck Surg. 2003;129(4):496. doi:10.1001/archotol.129.4.495-a