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Clinical Problem Solving: Pathology
April 2003

Pathology Quiz Case 1—Diagnosis

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Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Otolaryngol Head Neck Surg. 2003;129(4):487. doi:10.1001/archotol.129.4.485

Alveolar soft part sarcoma is a rare neoplasm, representing fewer than 1% of all soft tissue sarcomas.1 It is uniformly malignant, with no benign counterpart. Christopherson et al2 reported the first case of ASPS in 1952. This neoplasm occurs predominantly in adolescents and young adults, most often in the upper and lower extremities, and has a female predominance (female-male ratio, 2:1).1 The head and neck region is the second most common site in adolescents and young adults and is the most common site of occurrence in infants and children.1,2 Alveolar soft part sarcoma of the head and neck occurs most commonly in the orbit (41%) and the tongue (25%), followed by the neck, temporal, parotid, nasoethmoidal, and jugulodigastric regions.1,37 The tongue has seldom been reported as a primary site.8

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