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Clinical Note
June 2003

Utility of Tonsillectomy in 2 Patients With the Syndrome of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis

Author Affiliations

From the Department of Otolaryngology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY (Dr Parikh); the Department of Otolaryngology–Head and Neck Surgery, Virginia Commonwealth University, Richmond (Dr Reiter); and the Department of Otolaryngology and Communication Disorders, Children's Hospital Boston, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Mass (Drs Kenna and Roberson). The authors have no relevant financial interest in this article.

Arch Otolaryngol Head Neck Surg. 2003;129(6):670-673. doi:10.1001/archotol.129.6.670
Abstract

Objectives  To review the various causes of period fever in childhood, including the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA), and to examine the value of tonsillectomy in the treatment of PFAPA syndrome.

Design  Retrospective case series.

Setting  Urban and tertiary care referral children's hospital.

Patients  Two patients who underwent tonsillectomy for presumed recurrent adenotonsillitis were later diagnosed as having PFAPA syndrome.

Intervention  Tonsillectomy.

Main Outcome Measure  Frequency of PFAPA symptoms before and after tonsillectomy.

Results  No difference was found in the frequency of PFAPA symptoms after tonsillectomy.

Conclusion  Although a larger series of patients is required, our initial experience suggests that tonsillectomy is not always beneficial for patients with PFAPA syndrome.

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