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Clinical Problem Solving: Pathology
May 2006

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2006;132(5):557-558. doi:10.1001/archotol.132.5.557

Kaposi sarcoma was first described by Moritz Kaposi in 1872. Since then, several variants of KS, categorized according to their clinical features, have been described. Classic KS is an indolent disease that affects older men of Italian, Jewish, or Mediterranean descent. African or endemic KS is a relatively common neoplasm in equatorial Africa, with nodular, florid, infiltrative, and lymphadenopathic variants reflecting increasing clinical aggressiveness.1 Transplant-related, or acquired, KS occurs much more frequently in patients with posttransplant immunosuppression than in the general population. AIDS-associated or epidemic KS in patients with HIV is a Centers for Disease Control–indicated AIDS-defining illness that occurs much more frequently in patients with HIV than in the population at large, making it the most common AIDS-associated malignancy.2

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