Objectives: The objective of this study was to evaluate the positive predictive value of a thyroid nodule being malignant when described as atypical by the pathologist and to determine the usefulness of commonly reported cytopathological features in thyroid nodule fine-needle aspiration biopsy (FNAB).
Methods: This is a retrospective review of 111 consecutive patients who underwent thyroid surgery after presenting with an FNAB result categorized as atypical on cytopathological evaluation using Kini's criteria for the diagnosis of papillary carcinoma. An atypical FNAB result was designated when the specimen met 3 of the criteria or when the specimen had fewer than 3 but had other types of cytologic atypia.
Yehuda MN, Seaberg RM, Payne RJ, Freeman JL, MacMillan C. P012 Fine-Needle Aspiration Biopsy of the Thyroid: Atypical Cytopathology. Arch Otolaryngol Head Neck Surg. 2006;132(8):868. doi:10.1001/archotol.132.8.868-a