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Poster Presentations: American Head and Neck Society
August 2006

P033 Analysis of Intratumoral Concentration of S100 Protein in SCC of the Lower Lip, Predicting Metastasis and Survival

Arch Otolaryngol Head Neck Surg. 2006;132(8):871-872. doi:10.1001/archotol.132.8.871-c

Hospital das Clínicas University of São Paulo Medical School, Florianopolis, Brazil;

Hospital das Clínicas University of São Paulo Medical School, São Paulo

Objective: To study the relationship between intratumoral concentration of S100 protein and the development of metastasis in patients with squamous cell carcinoma of the lower lip and the impact on survival rates.

Methods: The charts of 66 patients with squamous cell carcinoma of the lower lip surgically treated at the Hospital das Clínicas University of São Paulo Medical School, Head and Neck Surgery Department, were retrospectively studied. Demographic, clinical, and pathological variables (pT, thickness, grade, margins, invasions, inflammatory infiltrate, and lymph node involvement) were analyzed and compared with intratumoral concentration of S100 protein (dendritic cells), identified by immunohistochemical assay. The overall and disease-free survival were compared among pathological variables using the Kaplan-Meier curves.

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