Objective: To determine if loss of expression of phospho–insulinlike growth factor (p-IGF) receptor IGF IR in human thyroid cancer specimens correlates with progression to anaplastic disease and responsiveness to anti–IGF-IR therapy.
Design: Retrospective histopathologic study with institutional review board approval
Subjects: Expression levels of IGF-I, pIGF-IR, IGF-IR, Akt, and pAKT were evaluated in 36 thyroid cancer specimens, 6 normal thyroid glands, and thyroid tissue arrays using an immunoperoxidase assay.
Chakravarty G, Yazici YD, Wang Z, Santillan AA, Jasser SA, El-Naggar AK, Myers JN. P060 Significance of Insulinlike Growth Factor Receptor I in the Development of Anaplastic Thyroid Cancer. Arch Otolaryngol Head Neck Surg. 2006;132(8):877. doi:10.1001/archotol.132.8.877-b