Ontario Cancer Institute and University Health Network, University of Toronto;
Ontario Cancer Institute and University Health Network, Toronto;
University Health Network, Toronto;
Mount Sinai Hospital, Toronto
Objectives: To determine the involvement of mismatch repair (MMR) genes in oral squamous cell carcinomas (OSCCs) from younger (<45 years) and older patients.
Design: Complementary DNA microarrays were used to determine gene expression profiles. A quantitative real-time polymerase chain reaction (Q-RT-PCR) was used to measure the expression of the mismatch repair genes hPMS1, hPMS2, and hMLH1. The PMS1 protein expression was analyzed by immunohistochemistry.
Machado J, Pintor dos Reis P, Galloni NN, Wang Y, Xu W, MacMillan C, Perez-Ordonez B, Gullane P, Irish J, Kamel-Reid S. P095 Investigation of the Mismatch Repair Genes hPMS1,hPMS2, and hMLH1 in Younger Patients With Oral Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):884. doi:10.1001/archotol.132.8.884-a