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Poster Presentations: American Head and Neck Society
August 2006

P100 Genetic Alterations in p53 in Head and Neck Cancer Cell Lines Change Cisplatin Sensitivity

Arch Otolaryngol Head Neck Surg. 2006;132(8):885. doi:10.1001/archotol.132.8.885-b

Objective: To understand the role of p53 in head and neck squamous cell carcinoma (HNSCC) cells in response to cisplatin treatment.

Design: The HNSCC cells that contain mutant (nonfunctional) p53 and high levels of the prosurvival protein Bcl-xL were transduced with wild-type (WT) p53, and HNSCC cells containing WT p53, also overexpressing Bcl-xL, were transduced with short interfering RNA p53 constructs. These transduced cell lines were compared with parental cell lines for sensitivity to cisplatin treatment.

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