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Poster Presentations: American Head and Neck Society
August 2006

P114 Vitamin D Inhibits Carcinogenesis in the Hamster Cheek Pouch Model

Arch Otolaryngol Head Neck Surg. 2006;132(8):887. doi:10.1001/archotol.132.8.887-b

Objective: To investigate whether systemic vitamin D3 (cholecalciferol) therapy prevents tumor formation in the hamster buccal pouch model.

Design: Randomized trial in which a known carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), was applied to the right buccal pouch of 20 golden Syrian hamsters 3 times per week. To evaluate vitamin D3 as a chemopreventive agent, animals were randomized to receive systemic vitamin D3 or no treatment. Animals were killed at 14 weeks after the initiation of DMBA exposure.

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