Objective: To investigate whether systemic vitamin D3 (cholecalciferol) therapy prevents tumor formation in the hamster buccal pouch model.
Design: Randomized trial in which a known carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), was applied to the right buccal pouch of 20 golden Syrian hamsters 3 times per week. To evaluate vitamin D3 as a chemopreventive agent, animals were randomized to receive systemic vitamin D3 or no treatment. Animals were killed at 14 weeks after the initiation of DMBA exposure.
Meier JD, Enepekides DJ, Albala J, Bradley C, Yunis R, Farwell DG. P114 Vitamin D Inhibits Carcinogenesis in the Hamster Cheek Pouch Model. Arch Otolaryngol Head Neck Surg. 2006;132(8):887. doi:10.1001/archotol.132.8.887-b