Roger Williams Medical Center, Providence, RI;
NorthMain Radiation Oncology, Providence
Objective: Radical radiation to the upper aerodigestive tree is associated with a high rate of tumor control but at the price of major quality-of-life impairment. A new treatment paradigm is under study.
Methods: Review of our database of patients with unknown primary head and neck squamous cell cancer (HNSCC) revealed 54 patients, 46 of whom had SCC nodal disease. Radical radiation with or without surgical resection was given to 39 patients (85%).
Wanebo HJ, Bhandari T, Radie-Keane K, Brotman R, Rathore R. P127 Radical Radiation for Unknown Primary Squamous Cancer Yields High Control But Has Major Toxic Effects, Suggesting the Need for a New Treatment Paradigm. Arch Otolaryngol Head Neck Surg. 2006;132(8):889. doi:10.1001/archotol.132.8.889-c