Objective: Over 400 000 cases of head and neck squamous cell carcinoma (HNSCC) were diagnosed in 2005 throughout the world, mainly in oral cavity and oropharynx. Alcohol and tobacco are the most important etiologic agents. Since 1983 it has been suggested that human papilloma virus (HPV) 16 might have a role in HNSCC carcinogenesis. Our objective was to determine HPV prevalence in patients with HNSCC.
Design: Presence of HPV was determined in fresh tumor tissue by polymerase chain reaction test and staged by hybridization in situ. We analyzed stage, tumor site, sex habits, and alcohol and tobacco consumption. Multiple regression analysis was performed.
Gallegos-Hernandez F, Hernandez D, Paredes E, Flores R, Minauro G, Arias H, Hernandez M, Resendiz J, Apresa T, Aguilar M. P160 Frequency and Types of Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):897. doi:10.1001/archotol.132.8.897-a