Objective: To examine the expression of EphB4 in cigarette-smoking and nonsmoking patients with head and neck squamous cell carcinoma (HNSCC) and to determine its role in tumor growth and metastasis, key factors associated with patient survival.
Design: Expression of EphB4 was determined by Western blot, real-time polymerase chain reaction, and immunohistochemical staining from fresh and archival tissues.
Setting: University medical center otolaryngology–head and neck surgery department.
Sinha UK, Mazhar K, Chinn SB, Vaninder D, Liu L, Masood R, Rice DH. P192 The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):901. doi:10.1001/archotol.132.8.901-b