Objective: We have developed the conductive interstitial thermal therapy (CITT) device as a means to deliver precision controlled energy to targeted tissues. Our objective was to use animal studies to demonstrate that CITT technology is a feasible adjunct to obtain negative surgical margins in head and neck cancer following primary tumor resection.
Design: A prototype CITT device was designed specifically for animal studies. The probe is inserted into the tumor itself and/or the excised tumor cavity. Initially, tumor ablation efficacy was assessed using the female rat model with mammary adenocarcinoma model flank tumors. Subsequently, human squamous cell carcinomas were ablated in the nude mouse model. The study consisted of 10 treated mice and 5 untreated control mice.
Spring PM, Kaufman Y, Hennings L, Stack BC, Suen JY, Shafirstein G. P199 Securing Negative Margins at Surgery Using Conductive Interstitial Thermal Therapy. Arch Otolaryngol Head Neck Surg. 2006;132(8):904. doi:10.1001/archotol.132.8.904-a