Objective: Antiplatelet and antithrombotic therapy have been widely used in microvascular free tissue transfer to reduce the risk of anastomotic failure and improve patency rates, especially in cases of perioperative trauma or vascular malpositioning. Our objective was to investigate the effect of preoperative aspirin administration on improving patency of microvascular anastomosis after a crush injury to the vascular pedicle.
Design: A randomized, placebo-controlled animal study.
Shnayder Y, Karakullukcu MB, Huang A, Hart S, Civantos FJ. P207 The Efficacy of Perioperative Aspirin in the Survival of Rat Microvascular Free Flap Following Preanastomotic Injury. Arch Otolaryngol Head Neck Surg. 2006;132(8):905. doi:10.1001/archotol.132.8.905-a