Objective: Head and neck squamous cell carcinomas (HNSCCs) often inadequately differentiate and ulcerate, suggesting that surface microbial products may affect HNSCC pathogenesis. Monocyte-lineage cells (MCs) infiltrate HNSCC. Lipopolysaccharide (LPS) induces MCs to secrete interleukin 6 (IL-6), a STAT3-activating, vascular endothelial growth factor (VEGF) inducing cancer-supporting factor, and both MCs and IL-6 are associated with HNSCC progression. Our objective was to characterize carcinoma cell-supporting outcomes of LPS-HNSCC-monocyte interactions.
Kurago ZB, Lam-ubol A, Stone B, Stetsenko A. P210 Cancer-Supporting Factors Consistently Induced by Lipopolysaccharide–Squamous Cell Carcinoma–Monocyte Interactions. Arch Otolaryngol Head Neck Surg. 2006;132(8):906. doi:10.1001/archotol.132.8.906-a