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Poster Presentations: American Head and Neck Society
August 2006

P225 Genetic Analysis of Genes Involved in Signal Transduction Pathways in Oral Squamous Cell Carcinomas

Arch Otolaryngol Head Neck Surg. 2006;132(8):909-910. doi:10.1001/archotol.132.8.909-c

Princess Margaret Hospital, Toronto, Ontario;

Ontario Cancer Institute and University Health Network, Toronto;

Mount Sinai Hospital, Toronto;

Princess Margaret Hospital and University Health Network, Toronto;

Ontario Cancer Institute and University Health Network, University of Toronto

Objective: Oral squamous cell carcinomas (OSCCs) are malignant oral cavity tumors that account for 24% of all head and neck cancers. They are the sixth leading cause of cancer death worldwide. In a previous study, we determined the global gene expression profiles of primary OSCCs and identified a subset of deregulated genes that correlated with more advanced-stage tumors. A subset of these genes are involved in signal transduction genetic networks. Our objective is thus to examine the expression of these genes in OSCCs.

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