Princess Margaret Hospital, Toronto, Ontario;
Ontario Cancer Institute and University Health Network, Toronto;
Mount Sinai Hospital, Toronto;
Princess Margaret Hospital and University Health Network, Toronto;
Ontario Cancer Institute and University Health Network, University of Toronto
Objective: Oral squamous cell carcinomas (OSCCs) are malignant oral cavity tumors that account for 24% of all head and neck cancers. They are the sixth leading cause of cancer death worldwide. In a previous study, we determined the global gene expression profiles of primary OSCCs and identified a subset of deregulated genes that correlated with more advanced-stage tumors. A subset of these genes are involved in signal transduction genetic networks. Our objective is thus to examine the expression of these genes in OSCCs.
Thurnher D, Pintor dos Reis P, Galloni NN, Freeman J, Brown D, Gilbert R, Gullane P, Irish J, Kamel-Reid S. P225 Genetic Analysis of Genes Involved in Signal Transduction Pathways in Oral Squamous Cell Carcinomas. Arch Otolaryngol Head Neck Surg. 2006;132(8):909-910. doi:10.1001/archotol.132.8.909-c