[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.74.94. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Oral Presentations: American Head and Neck Society
August 2006

S002 Squamous Cell Carcinoma (SCC)-Monocyte-Endotoxin Interactions Affect Monocyte Phenotype, Function, and SCC STAT3 Activation

Arch Otolaryngol Head Neck Surg. 2006;132(8):838. doi:10.1001/archotol.132.8.838-a

Background: Epithelial integrity in head and neck squamous cell carcinoma (HNSCC) is often disrupted, and microbial products and inflammation are potentially important in HNSCC pathogenesis. “Pro-inflammatory” CD16-positive monocytes expand in various malignancies, but their role in HNSCC is not known. Monocyte-lineage cells (MCs) are associated with HNSCC progression, potentially in part because MCs produce interleukin 6 (IL-6) in response to endotoxin (lipopolysaccharide, LPS), and IL-6 stimulates activation of STAT3, important in carcinogenesis. However, MC phenotypes and functions in HNSCC have not been characterized.

First Page Preview View Large
First page PDF preview
First page PDF preview
×