Background: Epithelial integrity in head and neck squamous cell carcinoma (HNSCC) is often disrupted, and microbial products and inflammation are potentially important in HNSCC pathogenesis. “Pro-inflammatory” CD16-positive monocytes expand in various malignancies, but their role in HNSCC is not known. Monocyte-lineage cells (MCs) are associated with HNSCC progression, potentially in part because MCs produce interleukin 6 (IL-6) in response to endotoxin (lipopolysaccharide, LPS), and IL-6 stimulates activation of STAT3, important in carcinogenesis. However, MC phenotypes and functions in HNSCC have not been characterized.
Lam-ubol A, Hopkin D, Kurago Z. S002 Squamous Cell Carcinoma (SCC)-Monocyte-Endotoxin Interactions Affect Monocyte Phenotype, Function, and SCC STAT3 Activation. Arch Otolaryngol Head Neck Surg. 2006;132(8):838. doi:10.1001/archotol.132.8.838-a