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Oral Presentations: American Head and Neck Society
August 2006

S025 Biomarkers of Invasiveness in Oral Squamous Cell Carcinoma: A Cell Proteomic Approach

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Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Otolaryngol Head Neck Surg. 2006;132(8):844. doi:10.1001/archotol.132.8.844-a

Objective: To identify potential biomarkers of invasiveness in oral squamous cell carcinoma maintained in vitro and in vivo as an orthotopic model.

Design: A pilot proteomic study for the identification of cancer vs host protein biomarkers in head and neck carcinoma.

Subjects: Two cell lines were established from randomly picked oral squamous cell carcinoma tissues with distinct invasive phenotypes. The cell lines were implanted into the tongues of immunocompromised mice in order to understand the role of host-tumor microenvironment in tumor progression.

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