Background: We have previously identified the pharyngeal constrictors (PC) and the glottic and supraglottic larynx (GSL) as structures whose dysfunction after intensive chemoirradiation is a likely cause of dysphagia, and explored intensity-modulated radiotherapy (IMRT) strategies that spared these structures without compromising target doses (Int J Radiat Oncol Biol Phys. 2004;60:1425-1439). Early results of a clinical trial to validate these findings are presented.
Eisbruch A, Lyden T, Feng F, Haxer M, Kim H, Feng M, Chepeha D. S034 Intensity-Modulated Radiotherapy (IMRT) Aiming to Reduce Dysphagia: Early Dose-Effect Correlations. Arch Otolaryngol Head Neck Surg. 2006;132(8):845-846. doi:10.1001/archotol.132.8.845-b