Objective: Chemoradiotherapy is an integral component in the management of advanced head and neck cancer (AHNC) patients. Dysphagia may manifest in these patients due to many factors. We sought to define factors that acutely influenced swallowing function prior to and during concurrent chemoradiotherapy.
Methods: From November 1998 to August 2002, 222 eligible AHNC patients were treated on a multi-institution phase 2 protocol. Ninety-five of 132 patients treated at the University of Chicago had swallowing function assessed via oropharyngeal motility (OPM) study prior to and within 1 to 2 months following the completion of chemoradiotherapy. The Swallowing Performance Status Scale (SPSS), a summary score on a scale of 1 to 7 of oral impairment, pharyngeal impairment, aspiration, and diet, was given by a single senior speech/swallow pathologist. Higher scores indicated worse swallowing. Generalized linear regression models were formulated to assess the effects of patient factors, tumor factors, and treatment-related factors on the differences between SPSS score before and after treatment.
Salama JK, Vokes EE, List MA, Mell LK, Stenson KM, MacCracken E, Cohen EE, Blair E, Haraf DJ. S037 Advanced T Stage Is Associated With Improved Swallowing Following Concurrent Chemoradiotherapy in Head and Neck Cancer Patients. Arch Otolaryngol Head Neck Surg. 2006;132(8):846-847. doi:10.1001/archotol.132.8.846-c