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Oral Presentations: American Head and Neck Society
August 2006

S041 Identification of the Mechanism of 11q13 Amplification Leads to Detection of DNA Repair Defects in HNSCC Cell Lines

Arch Otolaryngol Head Neck Surg. 2006;132(8):848. doi:10.1001/archotol.132.8.848-a

University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa;

University of Pittsburgh School of Medicine;

University of Pittsburgh;

University of Pittsburgh Cancer Institute

Objective: To determine whether the initial step in 11q13 amplification, loss of distal 11q, including 3 critical genes involved in the DNA damage response pathway, MRE11A, ATM, and H2AFX, is associated with chromosomal instability.

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