University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa;
University of Pittsburgh School of Medicine;
University of Pittsburgh;
University of Pittsburgh Cancer Institute
Objective: To determine whether the initial step in 11q13 amplification, loss of distal 11q, including 3 critical genes involved in the DNA damage response pathway, MRE11A, ATM, and H2AFX, is associated with chromosomal instability.
Gollin SM, Parikh RA, White JS, Huang X, Baskaran R, Saunders WS, Bakkenist CJ, Reshmi SC. S041 Identification of the Mechanism of 11q13 Amplification Leads to Detection of DNA Repair Defects in HNSCC Cell Lines. Arch Otolaryngol Head Neck Surg. 2006;132(8):848. doi:10.1001/archotol.132.8.848-a