Omiya Medical Center, Saitama, Japan;
University of Michigan, Ann Arbor
Objective and Design: We previously reported that loss of chromosome 18q develops with tumor progression and is associated with significantly decreased survival in head and neck cancer patients. Galanin receptor 1 (GALR1), a Gi-protein–coupled receptor, maps within the common region of 18q loss and is frequently inactivated by methylation, which is consistent with the possibility that it might be a tumor suppressor gene. To investigate effects of GALR1 and its signaling pathways, we stably expressed hemagglutinin-tagged GALR1 in a human laryngeal carcinoma cell line (UM-SCC-23-GALR1) that expresses no endogenous GALR1.
Kanazawa T, Kommareddi P, Nair T, Misawa K, Misawa Y, Ueda Y, Carey TE. S043 Galanin Receptor Type 1 Inhibits Cell Proliferation in Squamous Carcinoma Cells via Erk1/2 Activation. Arch Otolaryngol Head Neck Surg. 2006;132(8):848. doi:10.1001/archotol.132.8.848-b