Objective: To determine the sensitivity and specificity of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) for papillary thyroid cancer (PTC) detection.
Design: SELDI-TOF-MS protein profiles of patients with PTC, benign nodular disease (BND), and healthy controls were analyzed to determine the sensitivity and specificity of SELDI assay for PTC detection. Data analysis was performed using Ciphergen Biomarker Wizards and Biomarker Pattern Software to process the spectral data and classify the disease status of the patients.
Moretz WH, Gourin CG, Terris DJ, Xia Z, Liu Z, Weinberger PM, Adam B. S060 Serum Protein Profile Analysis in Patients With Papillary Thyroid Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):851. doi:10.1001/archotol.132.8.851-a