Objectives: Cytoplasmic galectin-3 is overexpressed in papillary thyroid carcinoma (PTC) and may activate the β-catenin/Wnt pathway, resulting in altered cyclin-D1 levels. Nuclear galectin-3 has not been well studied in PTC. We sought to characterize the localization of galectin-3 in benign and malignant thyroid neoplasms and correlate this with alterations in β-catenin and cyclin-D1 expression.
Design: Immunohistochemical study of 116 paraffin-embedded archival specimens using tissue-microarray technique.
Weinberger PM, Adam B, Gourin CG, Moretz III WH, Bollag RJ, Lee JR, Terris DJ. S062 Nuclear, Cytoplasmic Expression of Galectin-3 Is Associated With β-Catenin/Wnt-Pathway Activation in Thyroid Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):851. doi:10.1001/archotol.132.8.851-b