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Oral Presentations: American Head and Neck Society
August 2006

S067 Successive Aberrations in Protein Expression From Healthy Mucosa to Invasive Head and Neck Cancer

Arch Otolaryngol Head Neck Surg. 2006;132(8):853. doi:10.1001/archotol.132.8.853-b

ENT University Hospital, Heidelberg, Germany;

German Cancer Research Center, Heidelberg;

VTT Biomedical Research Center, Turku, Finland

Objective: To further define the development of head and neck squamous cell carcinoma (HNSCC) by the process of field cancerization.

Design: Analysis of protein lysates by surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and identification of candidate biomarkers by MS. Validation of differential protein expression by immunohistochemistry (IHC) on tissue microarrays.

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