UCLA Medical Center, Los Angeles, Calif;
UCLA School of Dentistry, Los Angeles
Objective: Using a salivary transcriptome approach, we have already identified 7 potential human RNA biomarkers in oral cavity/oropharyngeal squamous cell carcinoma (OSCC). The objectives were to investigate whether these 7 or other gene(s) change their expression levels after surgery.
Design: RNA isolation and linear amplification from saliva, followed by expression microarray analysis and quantitative polymerase chain reaction (qPCR) validation.
Nabili V, Yu T, Zhou X, Park N, Brinkman B, Pungpravat N, Abemayor E, Wong DT. S069 Saliva Array-Based Gene Expression Changes in Oral Squamous Cell Carcinoma: Presurgery and Postsurgery. Arch Otolaryngol Head Neck Surg. 2006;132(8):853-854. doi:10.1001/archotol.132.8.853-c