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Oral Presentations: American Head and Neck Society
August 2006

S069 Saliva Array-Based Gene Expression Changes in Oral Squamous Cell Carcinoma: Presurgery and Postsurgery

Arch Otolaryngol Head Neck Surg. 2006;132(8):853-854. doi:10.1001/archotol.132.8.853-c

UCLA Medical Center, Los Angeles, Calif;

UCLA School of Dentistry, Los Angeles

Objective: Using a salivary transcriptome approach, we have already identified 7 potential human RNA biomarkers in oral cavity/oropharyngeal squamous cell carcinoma (OSCC). The objectives were to investigate whether these 7 or other gene(s) change their expression levels after surgery.

Design: RNA isolation and linear amplification from saliva, followed by expression microarray analysis and quantitative polymerase chain reaction (qPCR) validation.

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