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Oral Presentations: American Head and Neck Society
August 2006

S079 Methylation of Multiple Genes as Diagnostic and Therapeutic Markers in Primary HNSCC

Arch Otolaryngol Head Neck Surg. 2006;132(8):857. doi:10.1001/archotol.132.8.857-a

Objective: Promoter methylation–mediated silencing is a hallmark of many established tumor suppressor genes. This study uses a novel, multigene approach to examine epigenetic events of aberrant promoter methylation as diagnostic markers in head and neck squamous cell carcinoma (HNSCC).

Design: DNA was interrogated for alterations in aberrant methylation status using the novel multigene (22 genes) methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.

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