Objective: PEG1/MEST is an imprinted gene expressed from the paternal allele and located on chromosome 7q32. In this study, we examined the expression and imprinting status of PEG1/MEST and IGF2 in head and neck cancer.
Methods: Head and neck squamous cell cancers and adjacent normal tissues from 19 patients were analyzed. For 6 of these cases we were able to analyze matched normal and cancer specimens.
Subjects: Seventeen oral squamous cancer cell lines were analyzed.
Kataoka H, Nakano S, Oshimura M, Kunimoto Y, Kitano H. S081 Loss of Imprinting of PEG1/MEST, IGF2 in Head and Neck Cancer. Arch Otolaryngol Head Neck Surg. 2006;132(8):857-858. doi:10.1001/archotol.132.8.857-c