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Clinical Problem Solving: Pathology
September 2006

Pathology Quiz Case 2: Diagnosis

Author Affiliations
 

FREDERIC B.ASKINMDWILLIAM H.WESTRAMD

Arch Otolaryngol Head Neck Surg. 2006;132(9):1015-1016. doi:10.1001/archotol.132.9.1013-b

Amyloidosis of the larynx is rare, representing fewer than 1% of all benign laryngeal lesions.1 Subglottic stenosis is usually traumatic in origin. Other benign etiologies include relapsing polychondritis, amyloidosis, sarcoidosis, and Wegener granulomatosis.2 Laryngeal amyloid deposits are characterized by extracellular subepithelial proteinaceous deposits, which may have a nodular or diffuse pattern.3 The disease occurs most commonly in the fifth to seventh decades of life, with a male predominance (male-female ratio, 2:1).2

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