Interdigitating dendritic cell sarcoma (IDCS) is a malignant neoplasm that arises from the interdigitating reticular cells of the lymph node. Dendritic cells are a heterogeneous group of antigen-presenting cells that play a major role in innate and adaptive immune responses. Subtypes of dendritic cells include Langerhans cells, interdigitating dendritic cells, follicular dendritic cells, and dermal dendrocytes.1 Interdigitating dendritic cells reside in the T-cell areas of peripheral lymphoid tissue, including the paracortex of lymph node and tonsil, the splenic periarteriolar lymphoid sheaths, and the interfollicular areas of mucosa-associated lymphoid tissue, and are responsible for major histocompatibility complex–restricted stimulation of resting T cells. Interdigitating dendritic cell sarcoma is rare; to our knowledge, only 34 cases have been reported to date.1- 4 Lymphadenopathy is the most common physical finding at presentation, and 42% of cases occur in the head and neck.1,2,4 Otolaryngologists evaluating a head and neck mass should therefore include IDCS in the differential diagnosis.
Jo S, Babb MJ, Hilsinger RL. Interdigitating Dendritic Cell Sarcoma of Cervical Lymph Nodes. Arch Otolaryngol Head Neck Surg. 2006;132(11):1257-1259. doi:10.1001/archotol.132.11.1257