A 61-year-old man presented with a 3-month history of dysphagia and subtle voice changes. Imaging demonstrated a cystic lingual mass. The patient underwent a transoral excision of the mass, which on microscopic examination showed a foregut duplication cyst with invasive, moderately differentiated adenocarcinoma involving the cyst wall. Malignancy arising in foregut duplication cysts in other areas of the body has been reported; however, to our knowledge, this is the first report of adenocarcinoma arising in a lingual foregut duplication cyst.
Volchok J, Jaffer A, Cooper T, Al-Sabbagh A, Cavalli G. Adenocarcinoma Arising in a Lingual Foregut Duplication Cyst. Arch Otolaryngol Head Neck Surg. 2007;133(7):717-719. doi:10.1001/archotol.133.7.717