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Clinical Problem Solving: Pathology
November 2007

Pathology Quiz Case: Diagnosis

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Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Otolaryngol Head Neck Surg. 2007;133(11):1168. doi:10.1001/archotol.133.11.1168

Ameloblastomas are benign but locally aggressive epithelial neoplasms that arise from undifferentiated odontogenic tissue. They are relatively uncommon, representing between 1% and 19% of all tumors and cysts in or around the mandible and maxilla.1 The most common site of origin is the mandibular molar region. Approximately 16% of ameloblastomas are found in the maxilla, with only 2% originating anterior to the premolar area.1,2 Maxillary ameloblastomas are generally thought to be more aggressive than mandibular ameloblastomas owing to the decreased bone density of the maxilla and the anatomical relationship to vital structures in the orbit and base of the skull.3

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