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Clinical Problem Solving: Pathology
June 21, 2010

Pathology Quiz Case 2

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2010;136(6):635. doi:10.1001/archoto.2010.67-a

A 64-year-old woman presented with a multinodular goiter. Cervical ultrasonography showed multiple nodules throughout the thyroid. Fine-needle aspiration and a core biopsy were perfomed. The fine-needle aspirate revealed a small clonal population of κ light-chain–restricted B cells. Although not diagnostic, this finding was suggestive of a lymphoproliferative process. Positron emission tomography–computed tomography demonstrated diffuse uptake throughout the thyroid, without evidence of lymphadenopathy or distant metastases. A bone marrow biopsy specimen showed normal cellular marrow. A right thyroid nodule was excised for diagnostic purposes. Pathologic examination revealed Hashimoto thyroiditis, without evidence of lymphoma.

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